Table 1. The list of significant associations with a gut microbiome data set.
Chr | Peak SNP | Position (Mb) | Associated region (Mb) | Number of genes | Clinical QTL | cis-eQTL | Overlapping with single genus GWAS |
---|---|---|---|---|---|---|---|
1 | rs31797108 | 182,072,111 | 18.1–18.2 | 21 | Body fat percentage increase | ||
2 | rs27323290 | 157,697,578 | 11.4–15.8 | 7 | Food intake, weight | Ctnnbl1 | Akkermansia muciniphila |
4 | rs28319212 | 95,462,396 | 82.1–10.5 | 74 | Food intake | Caap1, Ift74 | Oscillospira spp. |
6 | rs50368681 | 38,026,365 | 37.5–38.0 | 16 | Atp6v0a4, Replin1, Zfp467 | Sarcina spp. | |
7 | rs33129247 | 68,944,648 | 68.5–71.4 | 3 | TG, Gonadal Fat | Nr2f2, Igf1r | Akkermansia muciniphila |
11 | rs3680824 | 104,011,091 | 10.2–10.4 | 47 | Ccdc85a, Efemp1 | ||
14 | rs30384023 | 120,051,254 | 11.9–12.1 | 5 | Dnajc3, Uggt2, Farp1 | ||
16 | rs4154709 | 6,236,151 | 62.3–75.0 | 1 | |||
X | rs29064137 | 87,504,122 | 87.2–88.6 | 1 |
FaST-LMM (Lippert et al. 2011) is used for single genus GWAS. Chr, chromosome; Ctnnbl1, catenin, β-like 1; Capp1, caspase activity and apoptosis inhibitor; Ift74, intraflagellar transport 74; Atp6v0a4, ATPase, H+ transporting, lysosomal V0 subunit A4; Zfp467, zinc finger protein 467; TG, thyroglobulin; Nr2f2, nuclear receptor subfamily 2, group F, member 2; Igf1r, insulin-like growth factor 1 receptor; Ccdc85a, coiled-coil domain containing 85A; Efemp1, EGF containing fibulin-like extracellular matrix protein 1; Dnajc3, DnaJ (Hsp40) homolog, subfamily C, member 3; Uggt2, UDP-glucose glycoprotein glucosyltransferase 2; Farp1, FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1.