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. 2016 Oct 20;204(4):1379–1390. doi: 10.1534/genetics.116.189712

Table 1. The list of significant associations with a gut microbiome data set.

Chr Peak SNP Position (Mb) Associated region (Mb) Number of genes Clinical QTL cis-eQTL Overlapping with single genus GWAS
1 rs31797108 182,072,111 18.1–18.2 21 Body fat percentage increase
2 rs27323290 157,697,578 11.4–15.8 7 Food intake, weight Ctnnbl1 Akkermansia muciniphila
4 rs28319212 95,462,396 82.1–10.5 74 Food intake Caap1, Ift74 Oscillospira spp.
6 rs50368681 38,026,365 37.5–38.0 16 Atp6v0a4, Replin1, Zfp467 Sarcina spp.
7 rs33129247 68,944,648 68.5–71.4 3 TG, Gonadal Fat Nr2f2, Igf1r Akkermansia muciniphila
11 rs3680824 104,011,091 10.2–10.4 47 Ccdc85a, Efemp1
14 rs30384023 120,051,254 11.9–12.1 5 Dnajc3, Uggt2, Farp1
16 rs4154709 6,236,151 62.3–75.0 1
X rs29064137 87,504,122 87.2–88.6 1

FaST-LMM (Lippert et al. 2011) is used for single genus GWAS. Chr, chromosome; Ctnnbl1, catenin, β-like 1; Capp1, caspase activity and apoptosis inhibitor; Ift74, intraflagellar transport 74; Atp6v0a4, ATPase, H+ transporting, lysosomal V0 subunit A4; Zfp467, zinc finger protein 467; TG, thyroglobulin; Nr2f2, nuclear receptor subfamily 2, group F, member 2; Igf1r, insulin-like growth factor 1 receptor; Ccdc85a, coiled-coil domain containing 85A; Efemp1, EGF containing fibulin-like extracellular matrix protein 1; Dnajc3, DnaJ (Hsp40) homolog, subfamily C, member 3; Uggt2, UDP-glucose glycoprotein glucosyltransferase 2; Farp1, FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1.