Skip to main content
. 2016 Dec 16;12(12):e1006475. doi: 10.1371/journal.pgen.1006475

Fig 6. DDR-2 modulates SVH-1–SVH-2 signaling to regulate axon regeneration after neuron injury.

Fig 6

HGF/plasminogen-like protein SVH-1 is constitutively expressed in, and secreted from ADL sensory neurons in the head. Expression of SVH-2 is induced by axon injury. Following axon injury, DDR-2 accumulates at the severed end and is activated by EMB-9. DDR-2 facilitates the efficient activation of SVH-2 by SVH-1. Activated SVH-2 phosphorylates MLK-1 MAPKKK at a tyrosine residue, creating a docking site for SHC-1. SHC-1 constitutively forms a complex with MEK-1 MAPKK, and thereby functions to connect MLK-1 and MEK-1. SHC-1 participates in restricting the SVH-1–SVH-2 signal to the MLK-1–MEK-1 pathway.