Table 2. Domains, pathways and PPIs associated with the phenotype.
| ROI | Element | p-value | related genes |
|---|---|---|---|
| IPR001098 | 1.63 × 10−4 | POLG | |
| Domains | IPR001696 | 3.56 × 10−5 | SCN1A, SCN2A, SCN9A |
| IPR010526 | 2.99 × 10−5 | SCN1A, SCN2A, SCN9A | |
| IPR005821 | 9.59 × 10−6 | CACNA1A, CACNA1G, CACNA1H, KCNA1, KCNMA1, KCNQ2, KCNQ3, SCN1A, SCN2A, SCN9A | |
| hsa04930 | 1.2 × 10−6 | CACNA1A, CACNA1G, SLC2A2 | |
| Pathways | hsa04725 | 7.99 × 10−5 | CACNA1A, CHRNA4, CHRNB2, KCNQ2, KCNQ3, PLCB1 |
| hsa04728 | 1.18 × 10−6 | CACNA1A, GRIN2A, GRIN2B, PLCB1, PPP2R2C, SCN1A, SLC6A3 | |
| hsa05033 | 1.42 × 10−5 | CACNA1A, CHRNA4, CHRNB2, GABRA1, GABRB3, GABRD, GABRG2, GRIN2A, GRIN2B | |
| hsa04020 | 4.22 × 10−6 | CACNA1A, CACNA1G, CACNA1H, GRIN2A, PLCB1, PTK2B | |
| hsa04911 | 1.55 × 10−5 | ATP1A2, KCNMA1, KCNN3, PLCB1, SLC2A1, SLC2A2 | |
| hsa04919 | 2.71 × 10−4 | ATP1A2, NOTCH3, PLCB1, SLC2A1 | |
| hsa04976 | 1.75 × 10−4 | ATP1A2, SLC2A1 | |
| PPIs | UBC | 1.44 × 10−5 | FLNA, TUBA1A, UBE3A, SLC9A6, SLC1A3, PAFAH1B1, STXBP1, GPR56, NEDD4L, SLC2A1, ASPM, FANCI, TIMM17B, KCTD7, PLCB1, PDCD10, OPA1, NOTCH3, SCARB2, SLC25A22, HTT, DYRK1A, ATP6AP2, ALDH7A1, DMD, PQBP1, ARAF, TUBB2B, CSTB, TAP1, PTK2B, MECP2, TBC1D24, CNTNAP2, GRIN2A, CLCN2, PPP2R2C, POLG, STRADA, GABRD, CACNA1A, ATP1A2, MEF2C, KCNN3, SLC4A10, GABRB3, RBFOX1, JRK, PRICKLE1, TCF4, ARHGEF9, GRIN2B, SLC6A3, CASR, NHLRC1, EPM2A, OPRM1, GABBR1, CLN8 |
| SNTA1 | 4.24 × 10−6 | DMD, SCN1A, KCNJ10, SLC6A3 | |
| PSEN1 | 5.83 × 10−6 | SCN1A |
p-values and related genes of domain, pathway and PPI ROIs. Related genes associated to the phenotype are in bold font.