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. Author manuscript; available in PMC: 2016 Dec 16.
Published in final edited form as: Expert Opin Biol Ther. 2015;15(10):1531–1539. doi: 10.1517/14712598.2015.1090972

Figure 1.

Figure 1

Schematic representation of the biology of IL-5 [36], eosinophils and their mediators [29,73], and their effect on asthma. The point in this cascade where therapies targeting IL-5 or its receptor act is shown. Depletion of cells expressing IL-5Ra (eosinophils and basophils) results from antibody-directed cell-dependent cytotoxicity.

The HE-stained eosinophil was adapted with permission from wordpress.com [74].

Eos: Eosinophils; EPO: Eosinophil peroxidase; ILC2: Group 2 innate lymphoid cells; LTC4: Cysteinyl leukotriene C4; MBP: Major basic protein; MC: Mast cells; MMP-9: Matrix metalloproteinase 9; PAF: Platelet-activating factor.