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. 2016 Dec 12;9:179–189. doi: 10.2147/TACG.S122030

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© 2016 Lane et al. This work is published and licensed by Dove Medical Press Limited

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Liver findings in protoporphyric hepatopathy.

Notes: (A) Gross appearance of the liver showing pigmentary cirrhosis. (B–D) Representative microscopic images of the liver, including (B) the pigmented deposits of PP crystals (arrow) under light microscopy, (C) characteristic pink fluorescence indicative of differential excretion of PP in the liver under fluorescence microscopy (arrow), and (D) polarization microscopy. (E) Birefringence on polarization microscopy reveals visible Maltese cross patterns (arrow; D and E) within hepatocytes due to crystals of PP. (F) Electron microscopy demonstrating crystals of PP within hepatocytes (arrow). (Photos kindly provided by JR Bloomer, MD).

Abbreviation: PP, protoporphyrin.