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. 2016 Dec 12;9:179–189. doi: 10.2147/TACG.S122030

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© 2016 Lane et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Structural differences between afamelanotide and α-melanocyte stimulating hormone.

Notes: Afamelanotide differs from human α-MSH at the fourth and seventh amino acids, where norleucine replaces methionine (red) and d-phenylalanine replaces l-phenylalanine (red), respectively. These substitutions in the polypeptide confer unique biological properties, including resistance to enzymatic degradation, prolonged plasma half-life, and increased duration of action.35,36

Abbreviations: CID, PubChem compound identifier number; α-MSH, α-melanocyte-stimulating hormone.