Skip to main content
. Author manuscript; available in PMC: 2016 Dec 16.
Published in final edited form as: Nat Rev Mol Cell Biol. 2016 Mar 9;17(5):308–321. doi: 10.1038/nrm.2016.14

Figure 5. Pharmacological interventions in the DNA damage response that may lead to increases in lifespan and healthspan.

Figure 5

a | Inhibition of poly(ADP-ribose) polymerase 1 (PARP1) by olaparib and other PARP inhibitors has been shown to increase lifespan in model organisms. b | Impaired cellular metabolism can be counteracted by treatment with NAD+ precursors such as nicotinamide riboside (NR), by activation of NAD+-generating enzymes such as nicotinamide phosphoribosyltransferase by P7C3, or by replenishment of acetyl-CoA levels with ketones such as β-hydroxybutyrate (βOHB). c | Signalling factors and targets in the DNA damage response (DDR) may constitute additional targets for interventions. These include activation of sirtuin 1 by compounds such as SRT1720, or AMP-activated kinase (AMPK) activation using the AMP analogue AICAR. d | Mitochondrial function may be augmented by stimulation of autophagy by rapamycin or its newer analogues, or by stimulation of autophagy through alternative pathways using compounds such as spermidine.