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Cytotoxicity induced by SC13 is correlated with FEN1 expression level in cells. a. Cytotoxicity induced by SC13 on MCF7, as measured by MTT assay. b. Effect of SC13 on cell proliferation of MCF7 before or after FEN1 knockdown. c. Comparison of effect of SC13 on cell proliferation of MCF7 and MCF10A. d. Cytotoxicity assay of MCF7 cells co-treated with SC13 and PARP inhibitor. e. Effects of SC13 on MCF7 (WT) and HR-deficient cell line HCC1937 (BRCA−/−).
