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. 2016 Nov 10;14:32–43. doi: 10.1016/j.ebiom.2016.11.012

Fig. 7.

Fig. 7

SC13 enhances the sensitivity of cancer cells to chemotherapeutic agents. Cell staining with γ-H2AX antibody in MCF7 cells following treatment with (a) cisplatin, (b) 5FU, (c) TMZ alone, or with SC13. Drug sensitivity assay of MCF7 cells following treatment with (d )cisplatin, (e) 5FU, (f) TMZ alone, or with SC13. g. Comparison of sensitization of MCF7 and MCF10A to cisplatin by co-treatment with SC13. h. Effects of FEN1 knockdown on SC13 response of MCF7 cells. x, enhancement of growth inhibitory effect in MCF7 cells by co-treatment with SC13. y, enhancement of growth inhibitory effect in MCF7-SiFEN1 cells by co-treatment with SC13. i. SC13 combination with cisplatin decreases the growth of cancers in a xenograft model.