Fig. 3.

Promising novel drugs designed to target ageing. (A) NAD⁺ supplementation seeks to improve nuclear-mitochondrial communication in old cells and avoid accumulation of orphaned, hydrophobic electron transport chain subunits, thus aiding protein and organelle homeostasis. (B) Senolytic drugs act to remove senescent cells from tissues and thus ablate SASP (senescence-associated secretory phenotype) mediated tissue remodelling and restore regenerative capacity by removing SASP-induced restrictions of stem cell mobility and proliferation.