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. 2016 Dec 16;11(12):e0168651. doi: 10.1371/journal.pone.0168651

Fig 4. Impaired photoentrainment and light negative masking in Opn4::TeNT mice.

Fig 4

(A) Representative activity records from individual animals initially maintained under a 12:12 h LD cycle regimen for >2 weeks and then transferred to DD conditions for 2 weeks. A control animal demonstrates light entrainment in LD as indicated by enhanced activity in the dark period while the Opn4::TeNT mouse shows activity that follows a “free running” pattern. Shaded gray regions indicate periods of darkness. (B) Summary of measured periods (Tau) in control and Opn4::TeNT mice under LD and DD conditions. n = 12–13. (C) Activity records of control and Opn4::TeNT mice kept in ultradian light cycles of 3.5:3.5 light dark periods (T7). (D) Control mice are active mostly during dark periods under T7 conditions while the Opn4::TeNT mice are active across the light and dark periods. n = 4–5. *p<0.01. **; **p<0.001.