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Comparative pharmacokinetics of bixin (A) and norbixin (B) given orally. (A) bixin or (B) norbixin were given at 50 mg/kg. Plasma analyses—note that bixin is efficiently converted into norbixin (values are the mean of three different animals). (C) HPLC-MS/MS analysis of a mouse plasma sample following oral administration of 9’-cis-norbixin. Both norbixin isomers and glucuronide conjugates are observed. DAD: diode-array detector; MRM: multiple reaction monitoring.
