Fig 7. Effect of norbixin on ERG and retinal phototoxicity after BLD in the rat.

ERG from rat non-induced or light-exposed which received vehicle, norbixin or PBN. Recordings were on recovery day 7. (A) A- and b-wave amplitudes are presented for the six groups studied. (B) Representative pictures of retinal sections stained with Trichrome-Masson showing cell nuclei one week after BLD. Scale bars = 30 μm. (C) Morphometric analysis of retina. Photoreceptor cell nuclei were measured from the optic nerve to the superior and inferior side of the retina. Data from (A) and (C) represent the mean ± s.e.m. of two separate experiments with n = 3. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 compared to vehicle-treated group (One-way ANOVA, Dunnett’s post test).