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MiR-184 coordinately regulates aspects of angiogenesis. Schematic diagram showing that miR-184 targets PDGF-β and PPAP2B, which affects the activity of Akt and expression of Akt downstream genes MMP2 and MT1-MMP. Targeting FOG2 by miR-184 contributes to VEGF expression levels. Akt, PDGF-β, MMP2, MT1-MMP, and VEGF affect both proliferation and migration of endothelial cells, which ultimately regulates angiogenesis.
