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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Anesth Analg. 2017 Jan;124(1):346–355. doi: 10.1213/ANE.0000000000001662

Figure 1. The effects of sciatic neuropathy (CCI) on voluntary wheel running activity during the inactive phase of the diurnal cycle.

Figure 1

(A) Total distance traveled (m) steadily increased over a 7-day sequential habituation period of a fixed interval 1-hr/day free-access period to running wheels, while no differences were observed between groups (N = 8/gp) at any timepoint. Tukey’s test for timepoint comparisons and Šidák’ test for group comparisons at each time point. Statistical significance was set with alpha at p <0.05. (B) One hour wheel running activity after either sham surgery or unilateral sciatic nerve chronic constriction injury (CCI) revealed reduced activity in CCI rats relative to their baseline (BL) activity levels (BL indicated by a dashed horizontal line at ‘0’). Significant difference between sham- and CCI-treated rats using Tukey’s test for post-hoc contrasts. ** P < 0.01, # P < 0.02. (C, D and E) Within the one-hour activity assessment, three 20-min phases were analyzed with each phase revealing decreases in distance traveled after CCI at 1 or 2 of the 4 timepoints examined. Rats with CCI traveled the least on Day 18 during the first 20-min (phase I) of the 1-hr testing period. However, during the following 40 min (phase II and III), CCI rats consistently traveled less than sham controls on Day 10 and 14 after surgical manipulation. Significant differences between sham- and CCI-treated rats using Tukey’s test for post-hoc contrasts. ** P < 0.01, # P < 0.02, * P < 0.05.