Table 1.
Clinicopathologic characteristics of the 1406 patients with ER-positive, HER2-negative, node-negative breast carcinoma of recurrence score <18
| Total Patients (n=1406) |
Patients with RS 0–10 (n=510) |
Patients with RS 11–17 (n=896) |
|
|---|---|---|---|
| Age, years | |||
| Median (range) | 56 (22–90) | 60 (25–84) | 55 (22–90) |
| Mean | 57 | 59 | 56 |
| Age distribution, n (%) | |||
| <40 years | 63 (4%) | 21 (4%) | 42 (5%) |
| 40–49 years | 332 (24%) | 111 (22%) | 221 (25%) |
| ≥50 years | 1011 (72%) | 378 (74%) | 633 (71%) |
| Menopausal status, n (%) | |||
| Pre-menopausal | 471 (33%) | 157 (31%) | 314 (35%) |
| Post-menopausal | 902 (64%) | 346 (68%) | 556 (62%) |
| Peri-menopausal | 32 (2%) | 6 (1%) | 26 (3%) |
| Other a | 1 (0.1%) | 1 (0.2%) | 0 |
| Tumor size, cm | |||
| Median (range) | 1.2 (0.3–5.8) | 1.2 (0.4–5.8) | 1.2 (0.3–4.7) |
| Mean | 1.3 | 1.3 | 1.3 |
| Surgery, n (%) | |||
| BCS | 990 (70%) | 337 (66%) | 653 (73%) |
| Mastectomy | 416 (30%) | 173 (34%) | 243 (27%) |
| Radiation after BCS, n (% of BCS) | |||
| Yes | 937 (95%) | 323 (96%) | 614 (94%) |
| No | 53 (5%) | 14 (4%) | 39 (6%) |
| Endocrine therapy, n (%) | 1361 (97%) | 488 (96%) | 873 (97%) |
| Tamoxifen | 536 (38%) | 179 (35%) | 357 (40%) |
| AI | 728 (52%) | 279 (55%) | 449 (50%) |
| Tamoxifen >> AI | 48 (3.4%) | 10 (2%) | 38 (4%) |
| AI >> tamoxifen | 3 (0.2%) | 3 (0.6%) | 0 |
| Tamoxifen + OFS | 23 (1.6%) | 10 (2%) | 13 (1.5%) |
| AI + OFS | 12 (0.9%) | 2 (0.4%) | 10 (1.1%) |
| Tamoxifen >> AI + OFS | 6 (0.4%) | 3 (0.6%) | 3 (0.3%) |
| Other combinations b | 5 (0.4%) | 2 (1%) | 3 (0.3%) |
| Chemotherapy, n (%) | 170 (12%) | 22 (4%) | 148 (17%) |
| Median follow up (range), months | 46 (1–85) | 45 (1–82) | 46 (1–85) |
| Distant metastasis, n (%) | 6 (0.4%) | 1 (0.2%) | 5 (0.6%) |
Abbreviation: BCS, breast conserving surgery; AI, aromatase inhibitor; OFS, ovarian function suppression.
a
One patient is male.
b
Other combinations include: tamoxifen + OFS >> AI + OFS (n=2); tamoxifen + OFS >> AI (n=1); AI + OFS >> tamoxifen (n=1); tamoxifen >> OFS >> AI (n=1)