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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Curr Opin Genet Dev. 2016 Oct 13;41:140–149. doi: 10.1016/j.gde.2016.09.007

Figure 1. Observed genome-wide patterns of heterozygosity and linkage disequilibrium (LD) among worldwide human populations as functions of geographic distance from Addis Ababa, Africa (9 N, 38 E).

Figure 1

Haplotype heterozygosity (panel A, calculated as in Conrad et al. [95]) and average LD at 10kb (panel B, measured by r2) were calculated across 640,034 SNPs genotyped in the Human Genome Diversity Panel [7]. Note error bars are smaller than symbols. Equations for fitted lines and each linear model’s coefficient of determination are displayed within each panel. Symbols indicate geographic regions: red circles = Africa, orange left-pointing triangles = Middle East, yellow squares = Europe, green down-pointing triangles = Central/South and East Asia, blue right-pointing triangles = Oceania, purple up-pointing triangles = Americas; populations are assigned to regions as in Rosenberg et al. [38].