Table 1.
Demographic and clinical characteristics of survivors.
| DS & AML n=26 | AML, No DS**: (n=21) | P value*: | |
|---|---|---|---|
| Age at diagnosis | |||
| median in years (range) | 1.8 (0.77-10.9) | 1.5 (0.06-4.8) | 0.27 |
| Age at interview | |||
| median in years (range) | 15.0 (8.3-27.6) | 10.6 (8.1-18.3) | 0.003 |
| Time since diagnosis | |||
| median in years (range) | 12.8 (6.8-19.6) | 8.7 (6.7-18.1) | 0.003 |
| QOL physical summary score median (range) | 45.8 (10.0-58.7) | 54.0 (6.4-57.4) | 0.16 |
| QOL physical summary score mean (SD) | 41.2 (15.0) | 47.7 (12.2) | 0.11ˆ |
| QOL psychosocial summary score median (range) | 45.6 (28.0-59.1) | 50.3 (15.5-62.1) | 0.28 |
| QOL psychosocial summary score mean (SD) | 45.3 (8.4) | 46.3 (13.6) | 0.75ˆ |
| Gender | 0.63 | ||
| Male | 13 (50%) | 9 (42.9%) | |
| Female | 13 (50%) | 12 (57.1%) | |
| Race | 0.55 | ||
| White (including Hispanic) | 22 (84.6%) | 19 (90.5%) | |
| Nonwhite | 4 (15.4%) | 2 (9.5%) | |
| Treatment study | 0.003 | ||
| CCG213/213P | 8 (30.8%) | 0 | |
| CCG 251 | 5 (19.2%) | 1 (4.8%) | |
| CCG2891 | 13 (50.0%) | 20 (95.2%) | |
| Chronic health conditions | 0.07 | ||
| Yes | 20 (76.9%) | 8 (50.0%) | |
| No | 6 (23.1%) | 8 (50.0%) | |
| Any severe chronic health condition (grade III or IV) | 0.40 | ||
| Yes | 6 (23.1%) | 2 (12.5%) | |
| No | 20 (76.9%) | 14 (87.5%) | |
| Two or more chronic health conditions | 0.23 | ||
| Yes | 13 (50.0%) | 5 (31.3%) | |
| No | 13 (50.0%) | 11 (68.7%) | |
| Three or more chronic health conditions | 0.39 | ||
| Yes | 8 (30.8%) | 3 (18.8%) | |
| No | 18 (69.2%) | 13 (81.2%) | |
| Reports general health | 0.57 | ||
| Excellent, very good or good | 23 (88.5%) | 15 (93.7%) | |
| Fair or poor | 3 (11.5%) | 1 (6.3%) | |
| Has pain as a result of cancer | n/a | ||
| Yes | 0 | 0 | |
| No | 26 (100.0%) | 16 (100%) | |
| Has anxiety as a result of cancer | 0.95 | ||
| Yes | 5 (19.2%) | 3 (20.0%) | |
| No | 21 (80.8%) | 12 (80.0%) | |
| Functional impairment | 0.002 | ||
| Yes | 18 (69.2%) | 3 (18.8%) | |
| No | 8 (30.8%) | 13 (81.2%) | |
| Activity limitation | 0.27 | ||
| Yes | 5 (19.2%) | 1 (6.7%) | |
| No | 21 (80.8%) | 14 (93.3%) | |
| Need help in personal cares | 0.06 | ||
| Yes | 8 (30.8) | 1 (6.3%) | |
| No | 18 (69.2%) | 15 (93.7%) |
*
2-sided P value based on Wilcoxon rank sum test for continuous measures (ˆ for P values from two-sample t-test) and Chi-square test for categorical measures.
**
Survivors without Down syndrome whose proxy caregiver completed the CHQ PF50. Of these 16 also completed the CCSS baseline questionnaire.