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. Author manuscript; available in PMC: 2017 Apr 3.
Published in final edited form as: Nature. 2016 Oct 3;538(7625):411–415. doi: 10.1038/nature19785

Figure 2. Neurotransmitter binding site.

Figure 2

a, Competition experiments against [3H]-epibatidine. Calculated inhibition constant (Ki) values assume a Kd for [3H]-epibatidine of 96 pM (Extended Data Fig. 2d). n = 4 independent experiments. Error bars are s.e.m. and nH is the Hill coefficient. *Published range of the Ki of the ligands against WT α4β2. b, Extracellular view, with colored boxes indicating the three different interface classes. c–e, Architectural details of interfaces boxed in b. The top row is from the same orientation as in b. Nicotine and interacting residues are shown as sticks. Potential hydrogen bonding and cation-π interactions are represented as dashed lines (2.7–5 Å). In the lower row, the loop C backbone is hidden to aid in clarity.