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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Nature. 2016 Aug 15;537(7619):239–243. doi: 10.1038/nature19346

Figure 1. Long non-coding RNA Morrbid is a critical regulator of eosinophils, neutrophils, and Ly6Chi monocytes.

Figure 1

(a) Human neutrophil and mouse granulocyte normalized RNA-seq and ChIP-seq tracks at the Morrbid locus.

(b) Single molecule Morrbid RNA FISH.

(c) qPCR expression of mouse (n=3; representative of 3 independent experiments) and

(d) human Morrbid in indicated cell-types and tissues (n=7).

(e) WT and Morrbid-deficient flow-cytometry plots and absolute counts (n=3-5; representative of 7 independent experiments).

(f-g) L. monocytogenes infection of WT and Morrbid-deficient mice. (f) Survival and weight loss (n=9, representative of 3 independent experiments). (g) CFUs/g from indicated organs (n=5; representative of 3 independent experiments).

Error bars show s.e.m. *p < 0.05, **p < 0.01, and ***p < 0.001 (two-sided t-test e,g, (right) f; Mantel-Cox test (left) f).

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