Extended Data Table 1.

Molecules with μOR activity identified in the initial screen

Cmpd	Structure	Rank	Tca	μOR Ki (μM)	Nearest ChEMBL μOR ligand
1		467	0.28	7.2
2		358	0.28	5.8
3		1281	0.30	13.8
4		1465	0.30	2.3
5		2418	0.31	4.7
6		2211	0.30	10.0
7		1140	0.30	2.5

^aThe ECFP4 Tanimoto similarity (T_c) to the most similar μOR ligand in ChEMBL16.