Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding and signalling properties of compounds 12 and PZM21
| 12 | PZM21 | |
|---|---|---|
| Ki(nM) | ||
| μOR | 42 | 1.1 |
| δOR | N.A. | 506 |
| κOR | 464 | 18 |
| nociceptin | N.D.a | N.D.a |
| Gi/o (Glosensor) | ||
| EC50(nM)|Emax(%) | ||
| μOR | 180 | 88 | 4.6 | 77 |
| δ0R | N.A.b | 1900 | 78 |
| κOR | N.A.b | N.A.b |
| nociceptin | 1400 | 43 | N.A.b |
| Arrestin recruitment (PathHunter) | ||
| EC50(nM)|Emax(%) | ||
| μOR | 940 | 9.4 | NA.a |
Not determined.
No measurable activity.
