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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Nature. 2016 Aug 24;537(7618):117–121. doi: 10.1038/nature19102

Extended Data Figure 9. Br-verapamil binding breaks symmetry.

Extended Data Figure 9

a, Alignment of the 4 subunits of CaVAb in complex with Br-verapamil showing the voltage sensor module (VSD) and the ends of S6 are different. b, Measuring the Cα distances between T206 residues in adjacent subunits shows that the channel is indeed asymmetrical with Br-verapamil in the pore.