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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Nature. 2016 Aug 24;537(7618):117–121. doi: 10.1038/nature19102

Extended Data Figure 2. Structural comparison of the binding modes of amlodipine, nimodipine, and UK-59811.

Extended Data Figure 2

a, Superposition of CaVAb in complexes with amlodipine (cyan), nimodipine (yellow), and UK-59811 (magenta) at the dihydropyridine binding site viewed from the side of the pore module. The side chains of dihydropyridine-interacting residues are shown in sticks. b, An Fo–Fc simulated annealing omit map contoured at 2.5σ for nimodipine. c, An Fo–Fc simulated annealing omit map contoured at 2.5σ for UK-59811. d, An Fo–Fc simulated annealing omit map contoured at 2.5σ for DMPC.