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a, Ba2+ currents for state-dependent block by different concentrations of UK-59811. b, State-dependent block of CaVAb by UK-59811 at 0 nM (black), 100 nM (green), 500 nM (red), 1 μM (blue), and 5 μM (brown). For each curve, n = 4–5 cells. c, Concentration-response curve for UK-59811. Data were fit with a Hill equation assuming a 1:1 binding. IC50 = 194 ± 22 nM, n = 4–5.
