Fig 2.

Upper: A, Axial MPRAGE image from a 51-year-old female patient (16 in Table 1) superimposed on the VOI (in yellow). Orange lines show the 9 × 6 voxel CSI grid; voxels that passed the selection criteria to calculate the NAA concentration are highlighted in transparent red. B–D, SPM12-generated WM (B), GM (C), and CSF (D) masks also superimposed on the VOI CSI grid and selected voxels. Note the n ≥ 2 voxels that “passed” the selection criteria described in the “Materials and Methods” section.