Table 2.

Systemic Inflammatory Mediator Concentrations in Cases vs. Controls.

Mediator	Case (n=36) Median(IQR)	Control (n=40) Median (IQR)	Mann-Whitney U Test (p value)
IFN-γ	4.1 (3.3–6.4)	3.5(3.0–6.2)	0.252
IL-10	0.3 (0.2–0.4)	0.3 (0.2–0.4)	0.113
IL-13	0.8 (0.8–0.8)	0.8 (0.8–0.8)	0.099
IL-1β	0.0 (0.0–0.0)	0.0 (0.0–0.0)	0.859
IL-2	0.1 (0.1–0.3)	0.1 (0.1–0.2)	0.713
IL-4	0.0 (0.0–0.0)	0.0 (0.0–0.0)	0.970
IL-6	0.8 (0.4–1.2)	0.5 (0.3–0.9)	0.138
IL-8	4.7 (3.8–6.1)	4.0 (3.1–5.0)	0.041
TNF-α	2.2 (1.8–2.6)	1.9 (1.5–2.3)	0.031
IL-12	140 (103–191)	130 (83–154)	0.131
IL-17	1.1 (1.1–2.3)	1.1 (1.1–1.1)	0.546
IL-5	0.3 (0.1–0.6)	0.3 (0.2–0.6)	0.983
IL-7	3.4 (2.1–5.6)	3.5 (2.2–5.9)	0.768
TNF-β	0.2 (0.1–0.2)	0.1 (0.1–0.2)	0.037
VEGF	43.4 (32.0–56.5)	35.1 (28.3–44.1)	0.065
IL-15	1.9 (1.6–2.0)	1.8 (1.5–2.0)	0.914
IL-16	183 (152–230)	190 (165–272)	0.349
IL-1α	0.9 (0.5–2.1)	1.2 (0.5–1.9)	0.971
Eotaxin	74.7 (62.7–104)	86.4 (62.0–108)	0.938
Eotaxin-3	18.8 (14.1–26.4)	22.3 (17.1–25.3)	0.399
IP-10	253 (170–361)	210 (155–329)	0.293
MCP-4	45 (32.2–60.6)	52.4 (38.6–69.7)	0.182
MDC	660 (481–824)	657 (532–746)	0.979
MIP-1α	5.5 (5.5–12.7)	5.5 (5.5–12.0)	0.494
MIP-1β	53.8 (38.9–68.0)	45.0 (37.8–62.0)	0.302
TARC	58.5 (30.8–101.0)	71.9 (38.9–124.0)	0.163
Flt1	47.5 (37.5–53.8)	47.5 (38.1–57.8)	0.881
PIGF	28.2 (22.5–34.2)	25.0 (18.8–28.1)	0.056
Tie2	6380 (5680–7530)	5550 (4830–6280)	0.008
VEGF-C	43.5 (33.9–68.2)	61.0 (42.9–93.7)	0.112
VEGF-D	540 (382–1060)	750 (453–2240)	0.172
bFGF	7.7 (2.0–22.8)	7.2 (4.4–32.3)	0.298
CRP	4010 (2010–10600)	2150 (775–5300)	0.034
SAA	3880 (2420–8640)	1980 (840–4160)	0.002
ICAM-1	421 (351–586)	379 (310–421)	0.007
VCAM-1	415 (340–462)	415 (344–484)	0.873

^*All concentrations are expressed in pg/ml except with the exception of CRP, SAA, ICAM-1 and VCAM-1, which are reported in ng/ml. IQR = Interquartile Range (Q1–Q3)