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Potency and Selectivity of siRNAs with 3′ end modified guide strands (position 21)
| X | On-target IC50 pM, (PIK3CB) | Off-target IC50 pM, (YY1) | Off/On ratio (YY1/PIK3CB) | Off-target IC50 pM, (FADD) | Off/On ratio (FADD/PIK3C |
|---|---|---|---|---|---|
| U | 15 ± 5 | 15 ± 5 | 1.0 | 8 ± 3 | 0.5 |
| 1-ER | 16 ± 5 | 680 ± 30 | 42.5 | 127 ± 53 | 7.9 |
| Triazole I | 173 ± 68 | > 1200 | > 6 | 614 ± 37 | 3.5 |
| Triazole II | 23 ± 1 | 74 ± 3 | 3.2 | 20 ± 1 | 0.9 |
