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Potency and Selectivity of siRNAs with 3′ end modified guide strand (position 20)
| Y | On-target IC50 pM, (PIK3CB) | Off-target IC50 pM, (YY1) | Off/On ratio (YY1/PIK3CB) | Off-target IC50 pM, (FADD) | Off/On ratio (FADD/PIK3C |
|---|---|---|---|---|---|
| A | 15 ± 5 | 15 ± 5 | 1.0 | 8 ± 3 | 0.5 |
| 1-ER | 200 ± 62 | > 1200 | > 6 | 340 ± 65 | 1.7 |
| Triazole I | 238 ± 87 | 1035 ± 242 | 4.3 | > 1200 | > 5 |
| Triazole II | 71 ± 8 | 216 ± 88 | 3.0 | 170 ± 106 | 2.4 |
