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. Author manuscript; available in PMC: 2017 Feb 8.
Published in final edited form as: Nature. 2016 Aug 8;537(7619):229–233. doi: 10.1038/nature19339

Extended Data Figure 5. Correlation between inhibition of parasite proteasome chymotrypsin-like activity and parasite growth inhibition by the GNF6702 compound series.

Extended Data Figure 5

IC50: half-maximum inhibition of indicated parasite proteasome; T. brucei EC50: half-maximum growth inhibition on T. brucei bloodstream form trypomastigotes; T. cruzi EC50: half-maximum growth inhibition on T. cruzi amastigotes proliferating inside 3T3 cells; data points correspond to means of 2 technical replicates; red circles: IC50>20 μM; yellow circles: IC50>20 μM and EC50>25 μM; data for 317 analogues are shown.