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. Author manuscript; available in PMC: 2017 Feb 8.

Published in final edited form as: Nature. 2016 Aug 8;537(7619):229–233. doi: 10.1038/nature19339

Extended Data Table 3.

Inhibition kinetics parameters of GNF6702 on L. donovani and T. cruzi proteasomes

	chymotrypsin-like activity		caspase-like activity		trypsin-like activity
	L. donovani	T. cruzi	L. donovani	T. cruzi	L. donovani	T. cruzi
Ki ± s.e.m. [μM]	0.055 ± 0.006^*	0.079 ± 0.003^*	> 10	> 10	> 10	> 10
Km ± s.e.m. [μM]	3.6 ± 0.60^*	2.6 ± 0.15^*	N.A.^†	N.A.^†	N.A.^†	N.A.^†
Mode of inhibition	non-competitive	non-competitive	N.A.^†	N.A.^†	N.A.^†	N.A.^†
R² (goodness of fit)	0.91	0.97	N.A.^†	N.A.^†	N.A.^†	N.A.^†

^*

mean ± s.e.m.; n= 3 technical replicates

^†

not applicable