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Pacritinib inhibits CSF-1R. (A) Monocytes were treated (5 minutes) with recombinant human CSF-1 (10 ng/mL) in the presence of ruxolitinib (5 μM), fedratinib (5 μM), pacritinib (1 μM) or vehicle control (DMSO). Total and phosphorylated CSF-1R was detected in cell lysates by sandwich ELISA (in triplicate). The ratio of phosphorylated:total CSF-1R is shown. (B,C) Phosphorylation of the CSF-1R targets indicated was examined by immunoblotting (B) or flow cytometry (C).
