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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Transfus Med Rev. 2016 Aug 17;31(1):26–35. doi: 10.1016/j.tmrv.2016.08.004

Figure 2. General approaches to RBC drug carriers.

Figure 2

(A) Slow drug release from drugs encapsulated within RBCs provides sustained delivery (B) Drug-loaded RBCs are phagocytosed and deliver drugs to cells of the reticuloendothelial system (such as macrophages) (C) Encapsulated enzymes act upon diffusible substrates (D) Surface loaded enzymes act on extracellular targets either constitutively or after activation by other proteins/enzymes to an active state (green), which may provide enhanced specificity.