Table 2.

Association of Baseline Chloride Levels and Components of Diuretic Response at 72 Hours

Clinical parameters from randomization to 72 hours	Models	Estimate: per 1 mEq/L increase in Chloride	Standard Error	P-value
Furosemide equivalent dosing (mg) (N=308)	Unadjusted	−28.29	4.68	<.001
	Adjusted**	−32.66	8.13	<.001
Diuretic efficiency (ml/40 mg furosemide equivalents) (N=298)	Unadjusted	17.04	4.77	<.001
	Adjusted**	27.98	8.33	<.001
Cumulative urine volume (ml) (N=259)	Unadjusted	−45.65	36.23	0.21
	Adjusted**	−23.97	61.69	0.70
Change in cystatin C (mg/L) (N=286)	Unadjusted	0.01	0.004	<.001
	Adjusted**	0.01	0.006	0.30
Cumulative sodium excretion* (mmol) (N=251)	Unadjusted	6.37	3.60	0.078
	Adjusted**	10.43	6.19	0.093
Weight change (lbs) (N=295)	Unadjusted	−0.16	0.08	0.052
	Adjusted**	−0.38	0.15	0.010
Change in NT-proBNP (pg/mL) (N=286)	Unadjusted	−98.78	50.38	0.051
	Adjusted**	−63.18	85.40	0.46

Abbreviation: NT-proBNP is amino terminus pro B-type natriuretic peptide.

^*Normalized to 24 hours

^**Multivariable adjustment for sodium, bicarbonate, and cystatin C