Table 1:
Sample characteristics of HIV-infected childrena
| Late ART (>12 wk) | Early ART (<12 wk) Interrupted | Early ART (<12 wk) Not Interrupted | P Value | |
|---|---|---|---|---|
| No. | 13 | 16 | 10 | |
| Sex | 4 M/9 F | 5 M/11 F | 6 M/4 F | .30 |
| Age at scan (yr) | 5.3 (0.30) | 5.4 (0.24) | 5.6 (0.43) | .20 |
| Age ART started (wk) | 36 (17) | 8 (2) | 8 (2) | <.01b |
| Time on ART (wk) | 241 (22) | 203 (59) | 285 (22) | <.01b |
| Time interrupted (wk)c | NA | 85 (90) | NA | |
| Clinical measures at baseline | ||||
| CD4 count | 2064 (711) | 1969 (1118) | 1720 (978) | .57 |
| CD4% | 37 (7) | 35 (10) | 30 (13) | .21 |
| CD8 count | 1751 (1109) | 1460 (675) | 1978 (945) | .34 |
| VL > 750,000 (%) (No.) | 69 (9) | 56 (9) | 40 (4) | .37 |
| 400 < VL < 750,000 (%) (No.) | 31 (4) | 44 (7) | 60 (6) | |
| Clinical measures within 6 mo of scan | ||||
| CD4 count | 1027 (392) | 1110 (460) | 1289 (592) | .58 |
| CD4% | 37 (8) | 34 (7) | 36 (10) | .49 |
| CD8 count | 902 (450) | 1083 (544) | 1087 (625) | .57 |
| VL > 750,000 (%) (No.) | 8 (1) | 0 | 0 | .14 |
| 400 < VL < 750,000 (%) (No.) | 23 (3) | 6 (1) | 0 | |
| Suppressed VL (%) (No.) | 69 (9) | 94 (15) | 100 (10) | |
Note:—NA indicates not applicable; VL, viral load.
a
Values are mean (SD).
b
Significant.
c
Calculated up to the time of scanning in 3 children who had not restarted ART.