Fig. 3.

Common degenerative events leading to RGC death in experimental glaucoma. Schematic representation of the morphological and functional alterations of OFF vs. ON RGCs at different stages of glaucomatous neurodegeneration. Although occurring on different time scales, ON and OFF cells (red and blue, respectively) experience initial synapse loss paralleled by reduction of light response and sensitivity (right plots), followed by dendritic shrinkage and reduction of the functional receptive field. Eventually there is RGC cell death, with earlier loss of OFF RGCs followed by loss of ON RGCs. INL: inner nuclear layer; IPL: inner plexiform layer; GCL: ganglion cell layer. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)