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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Biol Psychiatry. 2016 Jun 16;81(7):606–615. doi: 10.1016/j.biopsych.2016.06.010

Figure 2.

Figure 2

Systemic administration of the HCRT-R1 antagonist, SB-334867, reduces cocaine self-administration in both short access (ShA) and long access (LgA) rats. The bars represent mean number (+ SEM) of cocaine infusions under a progressive ratio (PR; left axis) schedule of reinforcement, which correspond to the ratio breakpoint (right axis). Administration of SB-334867 (30 mg/kg; 30SB) significantly decreased cocaine self-administration in LgA (n = 9) and ShA (n = 7) rats. **p < 0.01 versus vehicle (VEH).