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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Biol Psychiatry. 2016 Jun 16;81(7):606–615. doi: 10.1016/j.biopsych.2016.06.010

Figure 4.

Figure 4

Intra-CeA administration of the HCRT-R1 antagonist, SB-334867, blocks yohimbine-induced reinstatement of cocaine seeking in rats with a history of long access (LgA) to cocaine self-administration. The bars represent mean number (+ SEM) of cocaine infusions during the six-hour self-administration session. Rats were allowed to self-administer cocaine during escalation (ESC) and then underwent extinction (EXT) training with a saline self-administration substitution. Rats showed a significant reduction in FR1 responding following EXT. LgA rats were then pretreated with either vehicle (VEH) or SB-334867 (10 nmol; SB) bilaterally into the CeA before receiving a systemic injection of yohimbine (2 mg/kg; YOH). LgA rats showed a significant increase in FR1 responding following VEH + YOH treatments. In the same LgA rats, YOH-induced reinstatement of drug-seeking was attenuated with pretreatment of intra-CeA SB. Order of VEH and SB intra-CeA injections was counterbalanced to reduce order effects. ^^p < 0.01 versus ESC; **p < 0.01 versus EXT, #p < 0.05 versus VEH+YOH.