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. 2016 Dec 14;20(6):744–757. doi: 10.1016/j.chom.2016.10.012

Figure 7.

Figure 7

DAPK1 rs1964911 Is Associated with Increased Risk of Invasive Aspergillosis in HSCT Recipients

(A and B) Cumulative incidence of invasive aspergillosis at 24 months in recipients (C/C versus A carriers, p = 0.029) (A) and cumulative incidence of invasive aspergillosis at 24 months in recipient/donor combination (B) (full model, p = 0.029).

(C–G) DAPK1 gene expression (C) and production (D and E), NLRP3 expression (F), and IL-1β production (G) in macrophages isolated from peripheral mononuclear blood cells of subjects carrying diverse genotypes at rs1964911 stimulated with A. fumigatus conidia.

Normalization was performed on Gapdh for real-time PCR and on human β-actin for immunoblotting. For immunofluorescence, nuclei were counterstained with DAPI. Photographs were taken with a high-resolution microscope (Olympus BX51). Scale bars, 25 μm. Data (mean values ± SD) represent pooled results or representative images (immunofluorescence and immunoblotting) from three experiments. ∗∗p < 0.01, ∗∗∗p < 0.001, CC versus A+ genotype. None, unstimulated cells. See also Table S1.