Table 3. Multivariate analyses of risk factors regarding overall survival of all patients (n = 1, 712) using Cox Proportional Hazard Model.
| Covariate | HR | CI(95%) | P-value | |
|---|---|---|---|---|
| Gender (ref: female) | ||||
| Male | 1.39 | 1.00 | 1.93 | 0.048 |
| Age (ref: <65) | ||||
| 65–<75 | 1.38 | 1.02 | 1.87 | 0.037 |
| ≥75 | 1.92 | 1.20 | 3.06 | 0.007 |
| Stage (ref: I+II) | ||||
| III+IV | 1.64 | 1.07 | 2.50 | 0.022 |
| T classification (ref: T1, T2) | ||||
| T3, T4 | 1.42 | 1.10 | 1.84 | 0.008 |
| N classification (ref: No) | ||||
| N1, N2, N3 | 2.41 | 1.70 | 3.42 | <0.001 |
| Histological grade (ref: WD, MD) | ||||
| PD | 1.51 | 1.16 | 1.97 | 0.003 |
| Treatment (ref: surgery alone) | ||||
| Surgery + RT alone | 1.07 | 0.77 | 1.48 | 0.683 |
| Surgery + CT alone | 1.97 | 1.33 | 2.90 | 0.001 |
| Surgery + CCRT | 0.93 | 0.69 | 1.26 | 0.645 |
Notes.
- HR
- Hazard ratio
- CI
- Confidence interval
- WD
- Well differentiated
- MD
- Moderately differentiated
- PD
- Poorly differentiated
- RT
- Radiotherapy
- CT
- Chemotherapy
- CCRT
- Concurrent chemo-radiotherapy