Table 2.
Analysis of BCR-ABL-expressing cells in CFU-C and LTC-IC assays
| Patient | Clonogenic assays at day 0* |
Clonogenic assays on LTC-IC (week 5)† |
Tested colonies | ||||
|---|---|---|---|---|---|---|---|
| Individual CFU-Cs | Pools of 10 CFU-Cs | Individual LTC-ICs |
Pools of 10 LTC-ICs |
||||
| MS-5 | MS-5/HOXB4 | MS-5 | MS-5/HOXB4 | ||||
| 1 | 0/20 | 1/18 | 4/31 | 1/8 | 311 | ||
| 2 | 0/20 | 1/19 | 2/39 | 4/40 | ND | ND | 289 |
| 3 | 9/19 | 11/16 | 1/30 | 9/30 | ND | ND | 239 |
| 4 | 2/20 | 0/19 | 0/20 | 0/19 | 420 | ||
| 5 | 1/20 | 0/20 | 0/20 | 2/17 | 0/20 | 0/20 | 657 |
| 6 | 1/17 | ND | 23/24 | 12/43 | ND | ND | 84 |
| Tested colonies | 116 | 920 | 164 | 130 | 470 | 200 | 2000 |
ND indicates not done (insufficient clonogenic or LTC-IC–derived CFU-C growth).
*
Number of BCR-ABL–positive CFU-Cs per tested CFU-Cs.
†
Number of BCR-ABL–positive LTC-ICs per tested LTC-ICs.