TABLE 1.

Genotype of the mutant clones

Mutant clone	Mutations in PR
1	L10I, L24I, E35D, M36I, M46L, I54V, L63P, I64V, V82A
2	L10F, L24I, E35D, M36V, N37S, R41K, M46I, I54V, D60E, Q61E, I62V, L63P, I64V, V82A
3	L10F, I15T, E35D, M36V, N37S, R41K, I54V, D60E, Q61E, I62V, L63P, I64V, V82A
4	L10V, V32I, N37S, M46I, I47V, I62V, L63P, V77I, P79S, Q92K, I93L, C95F
5	L10F, V32I, E35D, M36I, M46L, I54V, L63P, I64V, V82A
6	L10I, E35D, N37D, L63P, A71V, T74P, I84V, L90M, I93L
7	L10I, E35D, N37D, M46I, I54V, L63P, A71V, T74P, I84V, L90M, I93L
8	L10I, V32I, M46I, I47A, I62V, L63P, V77I, Q92K, I93L, C95F
9	L10I, G48V, I54V, L63P, A71V, I72M, V77I, V82A, L90M, I93L
10	L10I, V32F, G48V, I54V, V56K, L63P, A71V, I72M, V77I, V82A, L90M, I93L
11	L10V, I15V, G16E, K20R, E35D, M36I, R41K, M46I, I50V, I54V, K55R, R57K, Q61G, I64L, A71V, I72R, V82A, L89I, L90M, Q92K