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. 2004 Sep;42(9):4169–4174. doi: 10.1128/JCM.42.9.4169-4174.2004

TABLE 3.

Effect of cotransfection with WT clone on the phenotypes of mutant viruses

Mutant clone Mean FC for LPV compared to WT ± SDa (% decrease in FC of the mutant upon cotransfection with WTb) at indicated % of WT DNA cotransfected
0% 9% 33% 50%
5 25.8 ± 4.1 13.5 ± 1.3 (48) 7.2 ± 1.2 (72) 6.7 ± 0.9 (74)
6 21.2 ± 7.2 7.9 ± 1.2 (63) 4.5 ± 1.0 (79) 2.8 ± 0.6 (97)
7 66.2 ± 21.1 29.6 ± 10.4 (55) 6.1 ± 1.2 (91) 3.0 ± 2.1 (95)
8 276.9 ± 27.4 140.9 ± 20.8 (49) 29.5 ± 6.6 (89) 9.0 ± 2.4 (97)
9 35.8 ± 11.8 21.1 ± 0.36 (41) 7.2 ± 0.7 (80) 3.1 ± 0.9 (91)
10 54.5 ± 6.6 24.4 ± 3.8 (55) 5.0 ± 1.7 (91) 3.0 ± 0.4 (95)
11 150.1 ± 17.1 132.6 ± 37.0 (11) 31.3 ± 2.8 (79) 16.7 ± 3.5 (89)
a

Values were determined from the formula IC50 of mutant either alone or in mixture/IC50 of WT pNL4- 3-Fluc. The mean changes in IC50 were derived from two or three independent experiments, and each experiment contains triplicates.

b

Values are calculated from the formula (FC of mutant in mixture/FC of mutant alone) × 100.