TABLE 2.
Analysis of the sequences of Sw/ON/42729 (H3N3), Sw/ON/K01477 (H3N3), and Sw/SK (H1N1) HA proteins at residues that define avian versus mammalian evolutionary lineages and/or receptor preferences
| HA analysis and amino acid residue positiona | Amino acid found in:
|
Amino acid(s) typical ofb:
|
|||
|---|---|---|---|---|---|
| Sw/ON/42729 and Sw/ON/K01477 | Sw/SK | Avian-lineage viruses and/or NAcα2,3Gal receptor use | Mammalian-lineage viruses and/or NAcα2,6Gal receptor use | NGcα2,3Gal receptor use | |
| H3 | |||||
| 143 | P | NAc | NAe | NAe | P/S |
| 155 | T | NAc | NAe | NAe | Y |
| 158 | G | NAc | NAe | NAe | G |
| 226 | Q | NAc | Q | L | NAf |
| 228 | A | NAc | G | S | NAf |
| H1 | |||||
| 77 | NAd | D | D | E | NAf |
| 138 | NAd | A | A | S | NAf |
| 145 | NAd | S | S | L | NAf |
| 155 | NAd | T | T | V/T | I/V |
| 159 | NAd | T | T | N/G | NAf |
| 186 | NAd | P | P | S | NAf |
| 190 | NAd | D | E | D | NAf |
| 194 | NAd | I | L | I | NAf |
| 225 | NAd | E/G | G | E | NAf |
a
All numbers are based on the H3 numbering scheme.
b
Lineage- and receptor-specific amino acids are based on previously published sequence analyses (8, 17, 34-36, 38, 48, 49, 51, 61).
c
NA, analysis applicable only to H3 HA analysis.
d
NA, analysis applicable only to H1 HA analysis.
e
NA, residue analyzed only in reference to NGc receptor analysis.
f
NA, residue not applicable to NGc receptor analysis.