TABLE 1.
Susceptibilities of 30 isolates of Sporothrix schenckii to itraconazole and terbinafine, including QC strains of Candida
| Species and group of isolates (n) or strain | Antifungal agent | MIC (μg/ml)a
|
% Resistant isolates | ||
|---|---|---|---|---|---|
| Range | 50% | 90% | |||
| S. schenckii | |||||
| Animal (10) | Itraconazole | 0.062-4.0b | 4.0 | 4.0 | 90 |
| Terbinafine | 0.007-0.125 | 0.062 | 0.125 | 0 | |
| Human (20) | Itraconazole | 0.031-4.0 | 0.062 | 4.0 | 25 |
| Terbinafine | 0.007-0.50 | 0.031 | 0.25 | 0 | |
| C. krusei ATCC 6258 (QC) | Itraconazole | 0.125-0.50 | 0.25 | 0.50 | 0 |
| Terbinafine | 4.0->4.0 | >4.0 | >4.0 | 100 | |
| C. parapsilosis ATCC 22019 (QC) | Itraconazole | 0.125-0.25 | 0.25 | 0.25 | 0 |
| Terbinafine | 0.25-0.50 | 0.25 | 0.50 | 0 | |
a
50% and 90%, MICs at which 50 and 90% of isolates, respectively, are inhibited.
b
Only one susceptible isolate, from a horse.