TABLE 2.

Patients' serological and histologic data

Patient group and no.	Intrahepatic HBV DNA level (no. of copies/ng of hgDNA)	Serum HBV DNA level (log10 copies/ml)	ALT concn (U/liter)	Necroinflammation statusa	Fibrosis statusa
HBeAg positive
1	511	7.82	74	Minimal	Mild
2	1,800	6.62	53	Mild	Moderate
3	2,360	8.26	175	Minimal	Cirrhosis
4	4,210	8.76	71	Mild	Moderate
5	4,310	7.05	43	Mild	Mild
6	5,460	8.49	124	Mild	Moderate
7	6,790	9.37	38	Mild	Mild
8	6,950	7.21	212	Mild	Moderate
9	9,460	8.75	57	Mild	Moderate
10	10,700	8.71	70	Mild	Mild
11	12,700	6.27	85	Mild	Mild
12	15,100	7.25	72	Mild	Moderate
13	21,300	8.94	83	Mild	Moderate
14	22,700	8.00	357	Mild	Moderate
15	55,500	9.56	95	Minimal	Moderate
Anti-HBe positive
16	0.158	4.07	21	Minimal	None
17	0.31	<2.30b	28	Minimal	Mild
18	1.14	4.29	38	Minimal	None
19	3.31	5.26	22	Minimal	None
20	5.10	4.57	25	Minimal	None
21	43.6	5.99	190	Mild	Moderate
22	79.2	3.22	28	Mild	Mild
23	101	4.71	32	Minimal	None
24	166	6.67	130	Mild	Moderate
25	254	6.79	41	Mild	Moderate
26	404	7.19	73	Minimal	Moderate
27	585	6.25	51	Moderate	Moderate
28	610	7.11	170	Mild	Mild
29	742	6.54	43	Moderate	Moderate
30	782	6.73	275	Minimal	Mild
31	1,050	7.70	216	Moderate	Mild
32	1,200	7.31	76	Moderate	Moderate
33	1,510	7.26	67	Mild	Moderate
34	2,230	7.10	85	Mild	Moderate
35	2,410	6.85	223	Minimal	None
36	3,250	9.16	154	Minimal	Cirrhosis
37	3,310	7.23	70	Mild	Moderate
38	5,120	6.86	153	Mild	Moderate
39	5,250	8.11	87	Minimal	Moderate
40	5,360	7.54	248	Moderate	Moderate
41	7,310	7.58	134	Minimal	Moderate

^aThe histologic classification are described in the Materials and Methods section.

^bUndetectable.