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A) Structures of lead compounds U and V. B) Compound U (10 μM) inhibits interaction of PHD2 and the PXLE-containing protein FKBP38 in a mammalian two-hybrid assay. C) Compound U (10 μM) shows no effect on a control Gal4-VP16 fusion protein. B and C) n=4 and Error bars represent standard deviation. ** = P < 0.01, n.s. = not significant
