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. Author manuscript; available in PMC: 2017 Dec 14.
Published in final edited form as: Chembiochem. 2016 Nov 11;17(24):2316–2323. doi: 10.1002/cbic.201600493

Figure 4.

Figure 4

A) Compound U1 is effective at inducing HRE-dependent luciferase activity in PHD1/3 DKO cells under hypoxia (2% oxygen). B) U1 increases levels of HIF1α in PHD1/3 DKO cells equivalent to DFO (10 μM) treatment under mild hypoxia (4% oxygen). Phd2 Hum/Hum mice show a trend towards increased C) renal Epo mRNA and D) serum Epo 6 hours after a single IP dose (20 mg/kg) of compound U1. E) Phd2 Hum/Hum mice show increased hematocrit following 4 days of twice-daily injection with compound U1 at a dose of 20 mg/kg/day as compared to vehicle control. Error bars represent SD. n=5 per group A) or 4 per group C to E). * = P < 0.05, *** = P < 0.001