TABLE 3.
Inhibitory effect of plant lectins against syncytium formation between persistently (wild-type or mutant) HIV-1-infected cells and uninfected Sup-T1 cells
| Test compound | EC50 (μg/ml) for cell culturea:
|
|||
|---|---|---|---|---|
| HUT-78/HIV-1 | HUT-78/GNA-2.1 | CEM/HIV-1 | CEM/GNA-2.1 | |
| GNA | 5.6 ± 2.9 | 29.0 ± 8.9 | 1.0 ± 0.20 | 25.4 ± 12.5 |
| HHA | 4.1 ± 1.9 | 15.0 ± 6.0 | 0.85 ± 0.10 | 19.0 ± 12.4 |
| NPA | 8.0 ± 2.0 | 34.0 ± 19.7 | 1.2 ± 0.25 | 26.7 ± 5.8 |
| CA | 27.5 ± 3.5 | 70.0 ± 42.4 | 2.1 ± 0.51 | 30.0 ± 0.0 |
| LOA | 0.8 ± 0.0 | 3.3 ± 1.1 | 0.63 ± 0.75 | 2.0 ± 0.71 |
| Cyanovirin | 0.2 ± 0.0 | 0.29 ± 0.18 | 0.12 ± 0.06 | 0.2 ± 0.0 |
| DS-5000 | 2.5 ± 0.0 | 2.2 ± 0.47 | 1.5 ± 0.0 | 0.75 ± 0.29 |
| T-20 | 1.7 ± 1.5 | 0.67 ± 0.63 | 0.35 ± 0.56 | 0.27 ± 0.36 |
| AMD3100 | 6.3 ± 5.5 | 3.3 ± 1.8 | 1.2 ± 0.87 | 2.7 ± 2.3 |
| UC-781 | >20 | >20 | >20 | >20 |
| Tenofovir | >25 | ≥25 | >25 | ≥25 |
a
EC50, compound concentration required to prevent syncytium formation between persistently HIV-1- or HIV-1 GNA-2.1-infected HUT-78 or CEM cells and uninfected Sup-T1 cells by 50%.