Skip to main content
. 2004 Oct;78(19):10460–10469. doi: 10.1128/JVI.78.19.10460-10469.2004

FIG. 2.

FIG. 2.

IFN-γ- and IL-10-producing cells are detected in response to class I predicted 9-mer epitopes derived from ARFP. The presence of IFN-γ-producing (A) and IL-10-producing (B) cells in the peripheral blood of 5 chronic HCV patients (patient 1, NT, genotype 1, HLA.A1, HLA.A24, HLA.B14, HLA.B44; patient 2, NT, genotype 1b, HLA.A1, HLA.A3, HLA.B7, HLA.B8; patient 3, NR, genotype 1, HLA.A2, HLA.B18, HLA.B35; patient 4, R, genotype 1b, HLA.A2, HLA.B18, HLA.B35; patient 5, SVR, genotype 1a, HLA.A24, HLA.A69, HLA.B51) was determined following in vitro stimulation with the following class I predicted HLA-A2- or HLA-B7-restricted peptide epitopes: peptide R7V (black bars), W7L (hatched bars), A7L (dotted bars), and G7L (white bars). The reactivity of PBMC from HCV-negative individuals against these same epitopes was evaluated and represented as the mean ± standard deviation of the results from nine and seven experiments with IFN-γ-producing cells and IL-10-producing cells, respectively. The dotted line on each graph represents the cutoff value of each assay determined as described in Materials and Methods.